An example of a disease to consider in this regard could be oculocerebrorenal syndrome of Lowe (OCRL), a neurodevelopmental condition characterized by phosphatidylinositol 4,5-bisphosphate accumulation on endosomal membranes due to inactivating mutations in the OCRL phosphoinositide 5-phosphatase (reviewed in Billcliff & Lowe, 2014; Clayton, Minogue & Waugh, 2013b). Here, OCRL is linked to oculocerebrorenal syndrome.