SLC2A9 and gout: [Note that rs6449173 and SNPs in strong LD were not amongst SNP pairs in Wei et al. (2014) exhibiting epistasis.] Combined with the evidence here for a genotype-dependent effect at SLC2A9 on variance, previous reports of non-additive GxE interaction at SLC2A9 (McAdams-DeMarco et al., 2013; Batt et al., 2014; Voruganti et al., 2014) and evidence for a population-specific influence of genotype to fructose response (Dalbeth et al., 2013), it is clear that this is an extremely complex urate and gout locus that will be very challenging to understand using genetic epidemiology.