SLC2A9 and gout: In particular, variants in SLC2A9 have a very large effect on urate levels (e.g., rs12498742) and gout [e.g., rs11942223; in strong linkage disequilibrium (LD) with rs12498742], explaining 2–3% of the variance in serum urate in European individuals and a substantially stronger effect in women than in men (Hollis-Moffatt et al., 2009; Köttgen et al., 2013).