Disruption of Erk1/2 in granulosa cells itself caused female infertility due to ovulation failure; and it was further shown that Erk1 and Erk2 are required for the LH-induced resumption of meiosis in oocytes and the attendant ovulation and luteinization (Fan et al., 2009). The gene discussed is MAPK3; the disease is female infertility.