We examined changes in the expression of GR mRNA, GR promoters, and GR protein in glucocorticoid-sensitive and resistant leukemia and multiple myeloma cells in response to stimulation of cAMP and glucocorticoid signaling in these cells, and examined the correlation of these changes with induction of cell death in these cells following stimulation of these signaling pathways. Here, NR3C1 is linked to leukemia.