In the glucocorticoid-sensitive MM.1S myeloma cells, although stimulation of the glucocorticoid and cAMP signaling pathways both stimulated upregulation of Bim protein expression, there was no further enhanced expression of Bim protein when both signaling pathways were stimulated together, even though there was enhanced promotion of apoptosis when both signaling pathways were stimulated. Here, BCL2L11 is linked to plasma cell myeloma.