Overexpression of PDE4B in patients with diffuse large B cell lymphoma (DLBCL) was associated with relapse after chemotherapy, and overexpression of PDE4B in DLBCL impinged on the same genes that are normally active in glucocorticoid resistance (Smith et al., 2005; Kim et al., 2011). This evidence concerns the gene PDE4B and diffuse large B-cell lymphoma.