A number of studies have pointed to Bim as being an essential mediator of glucocorticoid-induced apoptosis of leukemic, lymphoma and myeloma cells, in that Bim is upregulated in these cells following glucocorticoid treatment, and down regulation of the expression of Bim inhibits glucocorticoid-induced apoptosis (Wang et al., 2003; Abrams et al., 2004; Bachmann et al., 2005; Ploner et al., 2005; Lu et al., 2006; Iglesias-Serret et al., 2007; Lopez-Royuela et al., 2010; Jiang et al., 2011; Zhao et al., 2011; Heidari et al., 2012; Jing et al., 2015). This evidence concerns the gene BCL2L11 and lymphoma.