Consequently, lactate induces the expression of several HIF-1 target genes, among which vascular endothelial growth factor A (VEGFA) in normoxic oxidative tumor cells (Lu et al., 2005; De Saedeleer et al., 2012) and VEGF receptor-2 (VEGFR2) in normoxic endothelial cells (Sonveaux et al., 2012) and macrophages (Colegio et al., 2014) are key contributors to lactate-induced angiogenesis. This evidence concerns the gene KDR and neoplasm.