Accordingly, we illustrate here that the HUVECs that were instrumental to identify lactate-induced NF-κB activation (Vegran et al., 2011) are much more glycolytic than SiHa and HeLa tumor cells that served as oxidative archetypes to identify lactate-induced HIF-1 activation (De Saedeleer et al., 2012). The gene discussed is HIF1A; the disease is neoplasm.