In response to lactate, endothelial cells further increase their production of basic fibroblast growth factor (bFGF) through a mechanism that indirectly depends on HIF-1 (Sonveaux et al., 2012), and tumor-associated macrophages are polarized to the M2 protumoral phenotype (Colegio et al., 2014). This evidence concerns the gene HIF1A and neoplasm.