MAPT and frontotemporal dementia: I10 + 4 A > C mutation may be in a position not so critical to strongly influence exon 10 splicing; similarly, although the I9 – 10 G > T mutation was reported, segregating with FTD and increasing 4R tau isoforms (Malkani et al., 2006), I9 – 15 T > C mutation may be in a less critical position and have scarce effect.