– The 5′-upstream variant rs1880753, localized at 160 Kb from transcription start site of MAPT, is associated with PSP and CBD; this variant is in a conserved sequence across mammals which is a potential binding site for YY1 and BNCF/BNC transcription factors (Cruchaga et al., 2009). Here, MAPT is linked to supranuclear palsy, progressive, 1.