MAPT and tauopathy: Accordingly, therapeutic strategies for tauopathies should take into account all the possibly compromised functions of tau to be successful, targeting tau phosphorylation features and aggregation tendency, oligomer toxicity, MT destabilization/overstabilization (for review, see Boxer et al., 2013; Spillantini and Goedert, 2013; Gerson et al., 2014), as well as DNA and chromosome damage (Rossi et al., 2013, 2014b; Violet et al., 2014), a pathological aspect until now neglected.