Another mouse model which closely resembles ALS, featuring a deletion of the hypoxia response element of the vascular endothelial growth factor gene (VEGFδ∕δ), shows down-regulation of many of the transcripts seen in the present study including: Ldlr, Stard4, Hsd17b7, and Sqle (Brockington et al., 2010). This evidence concerns the gene HSD17B7 and amyotrophic lateral sclerosis.