GJB2 and ichthyosis: “Aberrant Cx26 hemichannels and keratitis-ichthyosis-deafness syndrome: insights into syndromic hearing loss” by Sanchez and Verselis, summarizes some of the aberrant Cx26 hemichannel properties that have been reported for mutants associated with keratitis-ichthyosis-deafness (KID) syndrome, a particularly severe Cx26-associated syndrome.