SERPINI1 and early-onset autosomal dominant Alzheimer disease: Other studies have suggested a role for neuroserpin in Alzheimer's disease, with neuroserpin hypothesized to be either beneficial by interacting with amyloid-beta peptides and altering their oligomerization (Kinghorn et al., 2006) or detrimental by reducing tPA-mediated clearance of amyloid-beta (Fabbro and Seeds, 2009; Fabbro et al., 2011).