We recently identified an enrichment of KCC2 non-synonymous (NS) alleles in French Canadian (FC) idiopathic generalized epilepsy (IGE) cases compared to controls that included two rare and functional IGE risk alleles (KCC2 R952H and R1049C; Kahle et al., 2014). The gene discussed is SLC12A5; the disease is juvenile myoclonic epilepsy.