Alzheimer’s disease (AD) is a neurodegenerative disease characterized by both amyloidopathy (Hardy and Higgins, 1992; Hardy, 2009; Pimplikar, 2009) and tauopathy (i.e., the intracellular accumulation of hyper-phosphorylated tau neurofibrillary tangles) (Selkoe, 2001). The gene discussed is MAPT; the disease is Alzheimer disease.