GRIA1 and Cognitive impairment: Yuen et al. found that repeatedly exposing rats to stress leads to ubiquitination of GluA1 and the NMDAR subunit NR1 in the prefrontal cortex by Nedd4-1 and Fbx2, respectively, and that this results in reduced levels of these receptors and reduced glutamatergic transmission, which may underlie the stress-induced cognitive deficits observed.