As mentioned above, transfection of Ad.MnSOD gene into nodose neurons reduces CHF-induced elevation of the mitochondrial superoxide, reverses CHF-decreased activation of the Nav channel and neuronal excitability in aortic baroreceptors (Tu et al., 2012), and improves CHF-impaired arterial baroreflex sensitivity (Zhang et al., 2014). Here, SOD2 is linked to congestive heart failure.