SOD2 and congestive heart failure: Additionally, transfection of the Ad.MnSOD gene into the NG also significantly restored CHF-blunted arterial baroreflex function, measured by responses of blood pressure and heart rate to electrical stimulation of the aortic depressor nerve, and reflex changes of heart rate and cardiac sympathetic nerve activity in response to changes of arterial blood pressure (Zhang et al., 2014).