RELA and congestive heart failure: Transfection of NFκB p65 shRNA into the NG not only normalized the phosphorylated NFκB p65 protein, but also significantly increased the protein expression and current density of Nav channels in CHF rats (Zhang et al., 2014), which indicates that NFκB p65 shRNA gene upregulates the protein expression of Nav channels in the NG from CHF rats through inhibiting the phosphorylated NFκB p65 protein.