In particular, some studies have found that CHF induces overexpression of the AT1R in several central regions including rostral ventrolateral medulla, nucleus tractus solitarius, paraventricular nucleus, and subfornical organ, etc (Liu et al., 2006; Wang et al., 2008; Zheng et al., 2009; Zucker et al., 2009; Llewellyn et al., 2014). This evidence concerns the gene AGTR1 and congestive heart failure.