Although current studies do not unveil the detail molecular mechanisms of how NFκB p65 shRNA increases the protein expression of Nav channels in the NG from CHF rats, hyperactivation of NFκB is considered to downregulate the protein expression and current density of Nav channels in nodose neurons from CHF rats, which is inconsistent with the common conception that NFκB binding with target gene activates the gene transcription (Ghosh et al., 1998; Valen et al., 2001; Frantz et al., 2003; McKenna and Wright, 2015). The gene discussed is NFKB1; the disease is congestive heart failure.