The literature inspection highlighted that for 9 members of the HRS (ATAD2, CSF-1, DLGAP5, KIF11, NCAPG, PGRMC1, RRM2, TOP2A, and WHSC1 - all of the acronyms are explicated in the abbreviation list), there are conspicuous data regarding their role in cancer and their potential use as prognostic markers or cancer therapeutic targets (supplemental Table S6). The gene discussed is TOP2A; the disease is cancer.