INS and type 2 diabetes mellitus: In the 2015 update to the position statement of the ADA regarding the management of T2DM, the use of agents that inhibit SGLT2 has been included as an option for dual therapy (in combination with metformin) or triple therapy (in combination with metformin plus a sulfonylurea, thiazolidinedione, dipeptidyl peptidase-4 inhibitor [DPP-4i], or insulin) [3].