Among the 23 mutations in primary BC, the frequency of mutations according to subtype was as follows: TN (43.5%), ER+ (34.8%), HER2+ (21.7%), and ER+/HER2+ (0%) for IHC and luminal A (39.1%), HER2-enriched (34.8%), and basal-like (26.1%) for PAM50 (Table S3). The gene discussed is ERBB2; the disease is breast cancer.