SAT1 and Hyperoxaluria: However, later studies showed that a) hyperoxaluria in male rats did not alter the renal expression of sat-1 mRNA or protein abundance (25), which is in accordance with our data in EG-treated male rats, and b) sat-1 was not important for oxalate secretion across the mouse duodenum, but its role in oxalate secretion may be confined to more distal parts of the intestine (60).