Consistent with enhanced proliferation, Ingenuity Pathway Analysis of the upregulated microarray gene cluster associated with the early occurring HFD and HFD-LFD tumors highlighted canonical pathways associated with proliferative processes (i.e., G1/S checkpoint regulation, G2/M DNA damage checkpoint regulation, cyclins and cell cycle regulation, antiproliferative role of TOB in T cell signaling, mTOR signaling, purine nucleotides de novo biosynthesis II, cell cycle control of chromosomal replication, and molecular mechanisms of cancer). The gene discussed is TOB1; the disease is cancer.