MTOR and cancer: Upregulated pathways included those involved in cell cycle regulation (i.e., G1/S checkpoint regulation, G2/M DNA damage checkpoint regulation, cyclins and cell cycle regulation, antiproliferative role of TOB in T cell signaling, cell cycle control of chromosomal replication) and organismal growth [i.e., mechanistic target of rapamycin (mTOR) signaling, purine nucleotides de novo biosynthesis II], genotoxic stress [i.e., growth arrest and DNA damage 45 (GADD45) signaling, eukaryotic initiation factor 2 (EIF2) signaling], and molecular mechanisms of cancer.