There was no significant difference in the incidence proportion of ER+ and ER− glandular, cribriform, or papillary carcinomas between the later-developing tumors in the HFD-LFD and LFD-HFD groups (i.e., HFD-LFD late tumors, 3 of 5 ER+; LFD-HFD tumors, 4 of 6 ER+). Here, ESR1 is linked to thyroid gland papillary carcinoma.