PARP1 and early-onset autosomal dominant Alzheimer disease: PARP1, a molecular sensor of DNA damage [30], is activated when DNA is damaged and is thought to play a role in a variety of diseases, such as diabetes [6, 22], arthritis [23], Parkinson’s and Alzheimer’s diseases, cerebral ischemia, traumatic brain injury [24], and some malignancies such as ovarian carcinoma [25].