We focused on animals (n ≥ 3 lines per mutant) expressing wild-type FUS (FUS(WT)) or one of five ALS/FTD mutants: FUS (R495X), FUS(R522G), FUS(R524S), FUS(P525L), and FUS501(which models several ALS/FTD-associated C-terminal truncating mutations) (Figure 1A). The gene discussed is FUS; the disease is amyotrophic lateral sclerosis.