Mutations in a growing list of RNA binding proteins (RBPs) including TDP-43, FUS, ataxin2, hnRNPA1, and B2, are associated with sporadic and inherited forms of amyotrophic lateral sclerosis and frontotemporal dementia (hereafter “ALS/FTD”) (van der Zee and Van Broeckhoven, 2014). This evidence concerns the gene HNRNPA1 and frontotemporal dementia.