We further detected the difference in production of the Ly6G+Ly6Clow subset of MDSCs (gated on CD45+ cells) in the bone marrow of CD11b−/− mice and CD11b−/− tumor-bearing mice (wild type mice were used as controls) and found that the CD45+ leukocyte and granulocytic Ly6G+Ly6Clow MDSC populations did not differ in the bone marrow of the C57, CD11b−/−, ApcMin/+ and ApcMin/+;CD11b−/− mice (Fig. 5b). The gene discussed is ITGAM; the disease is neoplasm.