ITGAM and neoplasm: Compared with the ApcMin/+ mice, IHC staining (Fig. 3a–c and supplementary Figure 3) and immunoblotting assay (Fig. 3d) indicated a significant increase in the expression of E-cadherin and decreased expression levels of β-catenin and cyclin D1, the downstream target of the Wnt/β-catenin pathway, in the tumor tissues but not in the adjacent normal tissue of the ApcMin/+;CD11b−/− mice.