Childhood eczema is very common, affecting over 20% of children aged 5 years or under at some point.1 Eczema can cause significant distress to children and their families due to sleep disturbance and itch.2, 3 Health and societal costs of eczema are thought to cause a similar economic burden to that for asthma.4, 5 The term atopic eczema (synonymous with atopic dermatitis) is widely used to denote a clinical phenotype, rather than those who are truly atopic defined by the presence of IgE-specific antibodies to common environmental allergens. The gene discussed is IGHE; the disease is Eczematoid dermatitis.