Other interferences have been observed at posttranslational level, for example via direct interactions with zinc-binding proteins involved in DNA repair, cell cycle control and tumor suppressor functions (Hartwig2010), the modulation of secondary messengers, e.g., ROS or intracellular Ca2+ or of protein kinases enhancing phosphorylation of transcription factors (Waisberg et al. 2003). This evidence concerns the gene WEE1 and neoplasm.