NF1 and neurofibromatosis: Patients with neurofibromatosis type 1 (NF-1), an autosomal dominant inherited genetic syndrome caused by the deletion/inactivation of NF1–a gene that codes for neurofibromin1 - a negative regulator of the RAS/mTOR pathway, are predisposed to developing many types of benign and malignant neural tumors [7].