The long time window of ASIC1a-RIP1 complex formation is consistent with the notion that acidosis occurs slowly and progressively in the ischemic brain and both acidosis and necroptosis contribute mainly to delayed ischemic brain injury (Degterev et al., 2005; Pignataro et al., 2007), a phase of neuronal damage with high clinical relevance because of the need for post-ischemic neuroprotection following stroke. Here, RIPK1 is linked to stroke disorder.