Furthermore, Prdm14 is repressed in normal somatic tissues but is aberrantly reactivated in human malignancies of various tissue origin, including leukemias and lymphomas, breast, testicular, and lung cancers (Carofino et al., 2013; Dettman et al., 2011; Nishikawa et al., 2007; Ruark et al., 2013; Zhang et al., 2013). The gene discussed is PRDM14; the disease is leukemia.