Given the known tumour-promoting role of c-Rel in B-cell lymphoma, we were surprised to find that Eμ-Myc/c-rel–/– mice had a significantly shorter overall survival (median survival 79 days) than Eμ-Myc mice (median survival 115 days; Figure 1f). The gene discussed is REL; the disease is B-cell non-Hodgkin lymphoma.