REL and lymphoma: However, a number of in vitro studies have, in addition to their known tumour-promoting activities, revealed tumour suppressor functions for NF-κB subunits.1 Moreover, previous reports using mouse models of c-Myc-driven lymphoma have demonstrated that through induction of therapy-induced senescence, NF-κB can function as a tumour suppressor in this context.27, 28 Importantly, previous studies of the role of c-Rel in lymphoma have used either patient cells or established laboratory cell lines.