Amplifications and gains of REL have been detected in ~50% of HL21, 22, 23 and 10–25% or 50% in two studies of primary mediastinal large B-cell lymphoma.4, 24REL has also been identified as a susceptibility locus for HL,25 whereas c-Rel nuclear localisation has been identified as a poor prognostic factor in both activated B-cell-like- and germinal centre B-cell-like-diffuse large B-cell lymphomas.26 This evidence concerns the gene REL and Hodgkins lymphoma.