Moreover BAG3 secretion does not appear to be a specific feature of humanPDAC cell lines, as we could detect BAG3 in sera from Pdx-Cre; KrasG12D,Ikkalpha f/f mice25 that spontaneously develop PDAC, while it wasundetectable in Pdx-Cre, Ikkalpha f/f mice that only develop pancreatitis (Fig. 1e). This evidence concerns the gene CHUK and pancreatitis.