SBDS and Shwachman-Diamond syndrome: Interestingly, the zebrafish model of Shwachman-Bodian-Diamond syndrome (SBDS; OMIM#260400), a well characterized defect of ribosome biogenesis associated with haematopoietic dysfunction and increased cancer risk, due to mutations of the SBDS gene, is also characterized by skeletal defects in addition to chronic neutropenia29.