Suppressed Ki67 and MMP2/9 expression by IHC in MALAT1 siRNA treated Tscca tumors suggested the tumor cell proliferation and ECM degradation capability were inhibited significantly (P < 0.05, Fig. 5d).And EMT markers including N-cadherin and Vimentin were suppressed in MALAT1 siRNA treated Tscca tumors (P < 0.05, Fig. 5d). The gene discussed is MMP2; the disease is neoplasm.