It has remained unclear whether monocyte-derived eNampt has biological effects on cardiomyocytes, but we found that plasma NMN was significantly increased in TAC-operated mice, and that treatment of rat neonatal cardiomyocytes with TAC-operated mouse serum induced significantly higher deacetylase activity of Sirt1. The gene discussed is SIRT1; the disease is persistent truncus arteriosus.