Compared with CADD phred-like scores of exonic ETV6 variants observed in the non-ALL controls (i.e., the ExAC cohort), the ALL-related ETV6 variants were significantly more likely to be damaging (mean CADD phred-like score of 25.6 vs 15.2; p<0.0001. Here, ETV6 is linked to acute lymphoblastic leukemia.