Although common in childhood ALL in general,28, 52 the ETV6-RUNX1 fusion is underrepresented in children who carry the ETV6 germline risk alleles (Table 2), and this mutual exclusivity might imply possible overlap in the molecular mechanisms by which somatic and germline ETV6 variations influence ALL leukemogenesis. Here, ETV6 is linked to acute lymphoblastic leukemia.