Meanwhile, the mRNA expression of pparγ, lpl, lxr, mttp, ldlr and cd36 was not affected by P-407, but the expression of liver inflammation marker mcp-1 (Fig. 5D) as well as the level of serum AST and ALT (Table S1) were dramatically reduced, suggesting improvement of steatosis and inflammation. The gene discussed is PPARG; the disease is steatosis.