Brett-Morris reported that SAT1 (spermidine/spermine-N1-acetyltransferase 1) promoted resistance to ionizing radiation (IR) in glioma that contributed to glioma cell radioresistance, and thus suggests that SAT1 may potentially be a therapeutic target to sensitize GBM to cancer therapies20. The gene discussed is SAT1; the disease is glioblastoma.