In previous studies, transcriptional regulation of IL8 by nuclear factor-kappa B (NF-κB), activator protein-1 (AP-1) and CCAAT/enhancer-binding protein (C/EBP) has been reported in a number of tissues and cell types including colonic epithelial cells, ovarian cancer cells and myometrial cells27, 28, 29, 30, 31, 32. This evidence concerns the gene JUN and ovarian cancer.