An in silico enrichment analysis demonstrated, for both comparisons NMOSD vs. CIS/RRMS and NMOSD vs. controls, a highly significant enrichment of the miRNAs deregulated in NMOSD in immune cells (CD15+, CD14+, CD56+, CD19+, and CD3+ cells) of relevance for NMOSD. This evidence concerns the gene CD19 and in situ carcinoma.