FOXP3 and congenital rubella syndrome: As shown in Fig. 4a, mRNA levels of forkhead box P3 (FOXP3; a Treg-specific transcription factor) and GATA3 (a Th2-specific transcription factor) were decreased in CRS mice, and imipramine co-treatment did not reverse the reduced FOXP3 and GATA3 mRNA.