To confirm whether the alteration of cytokine mRNA in the lymph nodes is related with the serum level, the circulating cytokines IL-4, IL-10, IFN-γ, TNF-α, IL-1β, IL-6, and IL-17 were measured by Bio-Plex® cytokine assay, and we confirmed the immunomodulatory effect of imipramine in CRS mice. The gene discussed is IL1B; the disease is congenital rubella syndrome.