However, a recent multicenter randomized controlled trial in which 146 patients were allocated to receive 2.5 mg vitamin D or placebo at baseline and 14, 28, and 42 days after starting standard TB treatment demonstrated that vitamin D did not significantly affect time to sputum culture conversion in the entire study population but significantly hastened sputum culture conversion in participants with the TT genotype of the TaqI VDR polymorphism [69]. The gene discussed is VDR; the disease is tuberculosis.