WEE1 and malignant colon neoplasm: Cladoniamide A is a nanomolar cytotoxic agent, thought to target vacuolar H+-ATPase [25], xenocladoniamide D is an inhibitor of the colon cancer cell line HCT-116 [23], arcyriaflavin A inhibits human cytomegalovirus replication in vitro, and K252c inhibits many protein kinases, such as protein kinase C [37].