BRMS1 is a part of a family that includes suppressor of defective silencing 3 (SUDS3 or mSds3) and BRMS1-like (BRMS1L or p40) [6, 7] and has been shown to selectively suppress metastasis without any inhibition of tumorigenicity of multiple human cancer cells including melanoma [8], ovarian cancer [9] and non-small cell lung cancer [10]. The gene discussed is BRMS1L; the disease is cancer.