SGCB and diabetes mellitus: Based upon the concept of cardioprotection by enhanced cGMP-signalling via chronic pharmacological activation of the sGC enzyme, we investigated in the present study whether long-term administration of the sGC-activator cinaciguat can preserve left ventricular (LV) systolic and diastolic function and prevent DM-associated myocardial alterations in the rat model of streptozotocin (STZ)-induced experimental type-1 DM.