Perhaps the strongest argument against the idea of considering ApoB100 as an anti-obesity target is the observation that mice that do not produce hepatic ApoB and VLDL (due to liver-specific deletion of microsomal triacylglycerol transfer protein or MTTP) did not show an altered fat tissue mass even under a high-fat diet (HFD) [10]. Here, APOB is linked to obesity due to melanocortin 4 receptor deficiency.