INSIG1 and fatty liver disease: Other notable hepatic genes down-regulated in WD included: a) Cyp51a1 and Fdps which have been genotype-associated with higher HDL-C levels [31] and NAFLD [32] in humans, respectively; b) Hmgcs1 which has been shown to be positively associated with HDL-C levels [33]; and c) Insig1 which is a gene that, when overexpressed in livers of Zucker diabetic fatty rats, attenuates hepatic steatosis [34].