Indeed, genetically-altered murine models (Ldlr−/−, and Apoe2-knock-in) have been shown to present robust hepatic inflammation (via NF-κB signaling) and steatosis within 21 days of high fat/high cholesterol feeding, although wild-type mice in this same study developed only ectopic fat deposition without overt inflammation [49]. Here, NFKB1 is linked to steatosis.