Regarding the fact that thyroid FNAC and Bethesda classification have a major role in the surgical management of thyroid nodules, the assessment of TSHr methylation status may be a useful marker adjunct to the cytological examination, in particular, aiding to differentiate papillary thyroid carcinomas from colloidal nodules, as well as follicular adenomas from follicular carcinomas. The gene discussed is TSHR; the disease is thyroiditis.