TSHR and thyroid gland disorder: Regarding the fact that thyroid FNAC and Bethesda classification have a major role in the surgical management of thyroid nodules, the assessment of TSHr methylation status may be a useful marker adjunct to the cytological examination, in particular, aiding to differentiate papillary thyroid carcinomas from colloidal nodules, as well as follicular adenomas from follicular carcinomas.