Papillary thyroid carcinomas (PTC group) significantly showed higher TSHr methylation status than benign colloidal nodules (B group, p = 0.013) and follicular adenomas (FN-B, p = 0.004) do; but no higher than in follicular carcinomas (FN-M, p = 0.115) or in AUS (p = 0.096). The gene discussed is TSHR; the disease is thyroid gland papillary carcinoma.