In addition, studies have been conducted showing the efficiency of aspirin treatment in MSCs-mediated cell therapy for treating immune-related disorders, as aspirin is capable of promoting immunoregulatory properties of BMMSCs via the 15d-PGJ2/PPARγ/TGF-β1 pathway and aspirin-pretreated BMMSCs significantly ameliorated disease activity and colonic inflammation of dextran sodium sulfate (DSS)-induced experimental colitis in a mice model [31]. This evidence concerns the gene PPARG and colitis.