These studies show that HLA-DR3 was significantly associated with membranous nephropathy in Chinese, French, British, Chilean, and North American [50,51,52], DR3 was also associated with the occurrence of diabetic nephropathy [24, 29, 30, 34, 35], and was protective against the occurrence of idiopathic IgA nephropathy [36]. The gene discussed is TNFRSF25; the disease is membranous glomerulonephritis.