ADCY5 and type 2 diabetes mellitus: Additionally, there was a strong upregulation of several K+ channel genes in Aldh1b1tm1lacZ null islets, including Kcnj11, a type 2 diabetes risk factor [38] (Fig. 5n and ESM Table 1), and expression of adenylate cyclases Adcy4 and Adcy5 was repressed (Fig. 5h and ESM Table 1).