The majority of atlastin 1 mutations are located in the GTPase domain, although some have been identified in the stalk, the BSE, as well as in the transmembrane domains [43] suggesting that membrane association that is common to both representatives of the dynamin family, dynamin 2 and atlastin 1, may be critical in the pathophysiology of HSP. Here, DNM1 is linked to hereditary spastic paraplegia.