INPP5D and Cutaneous abscess: Loss of either SHP-1 or SHIP1, both negative regulators of ITAM signaling, causes severe myeloproliferation, skin abscesses, and lung failure (Van Zant and Shultz, 1989; Shultz et al., 1993; Tsui et al., 1993; Helgason et al., 1998; Abram et al., 2013).