In our study, using an IgE-mediated food allergy mouse model, we provided evidence that the oral administration of low doses of allergens induced CD4+CD25+FoxP3+ cells in the intestinal mucosa, with an increased production of IL-10 and a concomitant suppression of IL-5, IL-13, IgE production and Teff responses. Here, CD4 is linked to food allergy.